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桑德拉·李医生是一位皮肤科医生，在洛杉矶地区工作长达15年之久。她专门从事患者皮肤不同部位的各种肿块和囊肿的去除工作，并在全国享有盛誉。安吉丽娜的左胸下有一个巨大的胸部肿块，这不仅影响了她的爱情生活，还大大降低了她的自信和价值。德拉诺是一个雄心勃勃但饱受压抑的年轻人，他的背上有一个神秘的、足球大小的肿块，这影响了他找到工作的能力，导致他最近无家可归。卡拉从密西西比州远道而来，带着她充满活力的美国南方的魅力来到洛杉矶，希望能摘除自己头皮上5个又大又痛的囊肿。还有，布伦达的前额有一个四英寸长的肿块，靠近她的左眼，非常危险。为了有勇气走出家门去工作，她不得不用头发遮住脸过自己的生活。对于每一个病例，李医生都通过仔细讨论和近距离体检来诊断肿块，并检查癌症或其它疾病的危险迹象，同时努力让病人保持冷静和舒适。 只有等她制定了计划后，医生和她的医疗助理团队才能准备...。Will & Grace are best friends. Will is a gay lawyer and Grace is a straight interior designer. They both live in New York. Grace is engaged to a real jerk, but when that relationship falls apart, she moves in with Will. This is only supposed to be until Grace finds a place of her own, but she and Will end up with each other as permanent roommates. Also in the cast are Jack, Will's flamboyant gay friend and Karen, Graces' secretary/assistant who doesn't really need to work because she married money several times.。